WebApr 15, 2015 · In THP1 cells, which contain the HAQ STING allele (H71, A230, R232, 293Q), the ML phosphate bridge conferred increased signaling of both adenosine and guanosine … WebSTING knockout dual reporter monocytes. THP1-Dual™ KO-STING cells were generated from THP1-Dual™ cells by stable knockout of the STING gene. STING (stimulator of interferon genes), alternatively known as …
THP-1 CRE-Luc2 - TIB-202-CRE-LUC2 ATCC
WebFurthermore, the variant hSTING haplotype (HAQ) found in the THP1 monocytic cell line has low intrinsic activity but responds to bacterial and metazoan CDNs. Very recently, a splice variant of hSTING, named MRP, has been identified in HeLa and 293T cells that acts as a dominant negative regulator of STING-mediated IFN production10. Webwhich contained the R232 version of STING was knocked in to THP1 cells in which the HAQ version was ablated, were procured from Invivogen, CA, USA. Stable cell line generation a) … deleted tiktok account access
IFI16 is required for DNA sensing in human macrophages …
WebTHP-1. TIB-202 ™. THP-1 is a monocyte isolated from peripheral blood from an acute monocytic leukemia patient. This cell line can be used in immune system disorder research, immunology research, and toxicology research. Note: These are suspension cells and floating cells are viable. WebJun 20, 2024 · DNA damage response inhibition does not induce a type I interferon response in THP1 or Jurkat cancer cells. Proliferation of acute monocytic leukaemia THP1 and acute T cell leukaemia Jurkat cells (Supplementary Table 1) was robustly inhibited by the potent Chk1 inhibitor V158411 [].THP1 cells have been routinely used to study the cGAS / STING … WebSep 10, 2024 · The inactivity could be because (a) G10 is not a STING agonist, (b) G10 does not activate the HAQ STING variant or (c) that THP1 cells are somehow resistant to G10. … fergie married andrew