Paracellin
WebJul 2, 1999 · In a lovely dance between clinical and basic science, the report by Simon et al. now reveals that paracellin-1 regulates the resorption of Mg 2+ through paracellular channels in the kidney tubule. Unlike other ions such as Na +, K +, and Ca 2+, which depend on active resorption, Mg 2+ is resorbed largely by transport through the …
Paracellin
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WebRemarkably, paracellin-1 was found to be homologous to the claudin family of tight junction proteins. This discovery provides a plausible explanation for the finding that different members of the claudin family of proteins are expressed in different epithelia. Claudin 16 (or paracellin-1) is expressed in the thick ascending limb of Henle where ... WebOct 1, 2008 · They found that FHHNC was caused by mutations in paracellin-1, which is now considered to be claudin-16. In the past few years, research in this area has proliferated, and several comprehensive general reviews of this have recently been published (89, 99, 103). In this article, we focus on reviewing recent discoveries …
WebJan 1, 2002 · Paracellin-1 expression was restricted to distal tubular segments including the thick ascending limb of Henle's loop, the distal tubule, and the collecting duct. The identification and ... WebJun 29, 2024 · Simon et al. (1999) identified CLDN16, which they called paracellin-1 (PCLN1), and found that it encodes a protein of 305 amino acids with 4 transmembrane domains and intracellular N and C termini. The PCLN1 protein shows sequence and structural similarity to members of the claudin family (see 603718), with 10 to 18% amino …
WebAug 1, 2007 · a Detection of paracellin-1 transcripts in human salivary glands by RT-PCR. A Gl. submandibularis, C Gl. parotis, E Gl. labialis, G Gl. sublingualis; B, D, F, H controls lacking reverse transcriptase. WebMutations in PCLN-1, which encodes the renal tight junction protein paracellin-1 (claudin-16), were identified as the underlying genetic defects. Comprehensive clinical data and the results of PCLN-1 mutation analysis of 25 FHHNC families with 33 affected individuals …
WebMay 1, 2006 · Although paracellin-1 (PCLN-1) is known to have a crucial role in the control of Mg 2+ reabsorption in the kidney, the molecular pathways involved in the regulation of PCLN-1 have not been clarified. We used FLAG-tagged PCLN-1 to investigate these pathways further, and found that PCLN-1 is phosphorylated at Ser217 by protein kinase …
Webexplore the effect of Mg2 transport modulators on the paracellin-1 gene promoter. Endogenous paracellin-1 mRNA and protein were detected in renal cell lines opossom kidney (OK), HEK293, and MDCT, but not in the fibroblast cell line NIH3T3. A 7.5-kb hPCLN-1 5 -flanking DNA sequence along with seven 5 -deletion products interurban half price burgerWebtermed paracellin-1 (PCLN-1), was determined (14) and sequence analysis showed that it en-codes a protein of 305 amino acids (Fig. 2A) with four transmembrane domains and intracel-lular NH 2 - and COOH-termini (11, 15). The PCLN-1 protein shows sequence and struc-tural similarity to members of the claudin family (Fig. 2A) (15, 16) and is the most interurban grill richardsonWebJun 6, 2007 · a Detection of paracellin-1 transcripts in human salivary glands by RT-PCR.A Gl.submandibularis, C Gl. parotis, E Gl. labialis, G Gl. sublingualis; B, D, F, H controls lacking reverse transcriptase.The 934 bp fragments represent the expected PCLN-1 mRNA transcript, the 474 bp fragment represents a novel splice variant. b Comparison of the … new gold sells blackwaterWebJul 2, 1999 · Renal magnesium ion (Mg2+) resorption occurs predominantly through a paracellular conductance in the thick ascending limb of Henle (TAL). Here, positional cloning has identified a human gene, paracellin-1 (PCLN-1), mutations in which cause renal … new gold saucer itemsWebA new protein, named paracellin 1 (PCLN-1), expressed in human thick ascending limb (TAL) tight junctions, possibly plays a critical role in the control of magnesium and calcium reabsorption, since mutations of PCLN-1 are present in the hypomagnesemia … new gold scanner for gold dustWebCLDN16. Claudin-16 is a protein that in humans is encoded by the CLDN16 gene. [5] [6] It belongs to the group of claudins . Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving … new gold sedarWebJul 2, 1999 · Here, positional cloning has identified a human gene, paracellin-1 ( PCLN-1 ), mutations in which cause renal Mg 2+ wasting. PCLN-1 is located in tight junctions of the TAL and is related to the claudin family of tight junction proteins. These findings provide … interurban food