Glutathione s-transferase mu 4

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August undefined, 2024

WebGlutathione S-transferase Mu 4 is an enzyme that in humans is encoded by the GSTM4 gene. Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega ... WebJun 1, 2016 · PDF ABSTRAK Latar belakang: Kemoterapi sering menimbulkan efek samping berupa toksisitas hematologi. Derajat toksisitas yang timbul sering dikaitkan... Find, read and cite all the research you ...

Glutathione S-transferase: a versatile protein family

WebMay 1, 2024 · GenBank Gene ID. M96234. GenAtlas ID. GSTM4. HGNC ID. HGNC:4636. General References. Comstock KE, Johnson KJ, Rifenbery D, Henner WD: Isolation and analysis of the gene and cDNA for a human Mu class glutathione S-transferase, GSTM4. J Biol Chem. 1993 Aug 15;268 (23):16958-65. WebSemin Cancer Biol 9: 349 –357, glutathione S-transferase P1 gene by promoter hypermethyl- 1999. ation in human neoplasia. Cancer Res 58: 4515–4518, 1999. 27. … fortier financial

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WebGlutathione S-transferase A1 is an enzyme that in humans is encoded by the GSTA1 gene. [3] Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. These … WebIn the animal kingdom, where GST has been most intensively investigated, nine gene families named alpha, mu, pi, theta, kappa, zeta, sigma, omega, and delta have so far … WebGlutathione S-transferase Mu 5. Gene. Gstm5. Status. UniProtKB reviewed (Swiss-Prot) Organism. Mus musculus (Mouse) Amino acids. 224. Protein existence. Evidence at protein level. Annotation score. 5/5. ... SFLDS00019 Glutathione_Transferase_(cytos 1 hit; SUPFAM. SSF47616 GST C-terminal domain-like 1 hit; dimensions of olympic sized swimming pool

Glutathione-S-transferase family of enzymes - ScienceDirect

Glutathione transferases: substrates, inihibitors and pro-drugs …

WebMay 1, 2024 · 138333 - GLUTATHIONE S-TRANSFERASE, MU-4; GSTM4 - GLUTATHIONE S-TRANSFERASE M4 - GSTM4 Ross and Board (1993) cloned and characterized GSTM4. Ross et al. (1993) reported that a probe derived from GSTM4 cross-hybridized with the other 3 known human mu class GST genes: GSTM1, GSTM2 … WebGlutathione S-transferase Mu 4 isoform 1, also known as GSTM4, is member of the glutathione s-transferase (GST) family of proteins. There are eight families of GST … fortier insurance servicesWebGSTM4 (glutathione S-transferase mu 4) haplotype 1101000 may be an important determinant for lung function growth; Observational study of gene-disease … dimensions of office desk

"WebAbstract. Human glutathione S-transferases (GSTs) are a functionally diverse family of soluble enzymes of detoxification that use reduced glutathione (GSH) in conjugation and reduction reactions. Toxic electrophiles, including a variety of carcinogens, are substrates for the GSTs and after conjugation or reduction they are more easily excreted ... " - Glutathione s-transferase mu 4

Glutathione s-transferase mu 4

WebAmong the cytosolic GST enzymes, the variations of mu, theta, and pi classes have intensively investigated in various studies. 19,20 The glutathione S-transferase mu 1 (GSTM1), glutathione S-transferase theta 1 (GSTT1), and glutathione S-transferase pi 1 (GSTP1) genes are polymorphic and some allelic variants cause enzyme deficiency. 9 WebAug 28, 2024 · Background: Pancreatic cancer (PC) is a lethal malignancy with an extremely unfavorable 5-year survival rate and a high mortality rate. Glutathione S-transferase mu-3 (GSTM3) has been shown to exert different functions in the progression and development of various cancers, except for PC. This study aimed to explore the role of GSTM3 in the …

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WebNov 1, 2024 · Regarding the detoxification pathways of platinum derivatives as well as paclitaxel, as the drugs most commonly used to treat metastatic ovarian cancer patients, glutathione transferases (GSTs) have been recognized as the major enzymes responsible for the conversion of these drugs into less effective forms [28].

WebBackgroundOvarian cancer (OC) is one of the most common types of gynecologic tumor over the world. The Glutathione S-transferase Mu (GSTM) has five members, including GSTM1-5. These GSTMs is involved in cell metabolism and detoxification, but their role in OC remains unknown.MethodsData from multiple public databases associated with OC … WebApr 3, 2024 · Glutathione S-transferases (GSTs) are ubiquitous enzymes that are encoded by a large gene family, and they contribute to the detoxification of endogenous or xenobiotic compounds and oxidative …

WebGlutathione S-transferase mu (GSTM) belongs to a family of phase II detoxification enzymes that catalyze the conjugation of reduced glutathione (GSH) to a wide range of … WebThe glutathione S-transferase protein family is important in detoxification within the cell and can protect the lens from oxidative stress [102]. Polymorphisms within the glutathione S-transferase Mu 1 (GSTM1) gene have been associated with increased risk for age-related cataracts, especially with exposure of smoking [103, 104].

WebJun 15, 2024 · The Glutathione S-transferase Mu (GSTM) has five members, including GSTM1-5. These GSTMs is involved in cell metabolism and detoxification, but their role in OC remains unknown.

The activity of GSTs is dependent upon a steady supply of GSH from the synthetic enzymes gamma-glutamylcysteine synthetase and glutathione synthetase, as well as the action of specific transporters to remove conjugates of GSH from the cell. The primary role of GSTs is to detoxify xenobiotics by catalyzing the nucleophilic attack by GSH on electrophilic carbon, sulfur, or nitrogen atoms of said nonpolar xenobiotic substrates, thereby preventing their interaction with crucial ce… dimensions of one slab of graniteWebJul 22, 2014 · Besides exhibiting antiproliferation action, butyrate also exhibits an antioxidant effect by augmenting cellular glutathione (GSH), reducing reactive oxygen species … fortier law officeWebGlutathione S-transferase mu 3 (GSTM3) is an enzyme that in humans is encoded by the GSTM3 gene. Glutathione S-transferases (GSTs) are a family of enzymes that play an important role in detoxification by catalyzing the conjugation of many hydrophobic and electrophilic compounds with reduced glutathione. Based on their biochemical, … fortier homes stoke on trentWebGene provides a unified query environment for genes defined by sequence and/or in NCBI's Map Viewer. LOC125355438 glutathione S-transferase Mu 4 [ (Pacific pocket mouse)] Gene ID: 125355438, updated on 20-May-2024. Summary Other designations. glutathione S-transferase Mu 4 ... fortier law firm sudburyWebGlutathione S‐transferase Mu 5 (GSTM5) mRNA expression is downregulated in patients with bladder cancer from the Oncomine database. Three mRNA databases exhibited different ex‐ dimensions of olympic poolWebGlutathione-S transferase (GST) is a most ancient protein superfamily of multipurpose roles and evolved principally from gene duplication of an ancestral GSH binding … fortier insuranceWebApr 6, 2024 · Glutathione-S-transferase mu 2 (GSTM2), as a member of phase II drug metabolizing enzymes (DMEs), regulates cellular antioxidant and detoxificant. GSTM2 was highly up-regulated in hepatic ... fortier law firm